Location History:
- Tampa, FL (US) (2015 - 2020)
- Temple Terrace, FL (US) (2019 - 2021)
Company Filing History:
11 out of 1,933 
3 out of 894 
Years Active: 2015-2021
Title: Umesh Kumar Jinwal: Innovator in Nanoparticle Delivery Systems
Introduction
Umesh Kumar Jinwal is a prominent inventor based in Tampa, FL (US), known for his significant contributions to the field of nanoparticle delivery systems. With a total of 11 patents, his work focuses on developing innovative solutions for drug delivery, particularly in the treatment of Alzheimer's disease and related tauopathies.
Latest Patents
Among his latest patents, Jinwal has developed glutathione-coated nanoparticles for the delivery of MKT-077 across the blood-brain barrier. This nanoparticle-based formulation encapsulates MKT using poly(ethylene glycol)ylated (PEGylated) poly-(lactide-co-glycolide) (PLGA) to form nanoparticles (NPs). The glutathione (GSH) coating enhances the permeability of these nanoparticles across the blood-brain barrier (BBB). The newly generated MKT-NPs have demonstrated BBB permeability and tau reduction in experimental models, making them a promising therapeutic option for Alzheimer's disease.
Another notable patent involves the preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies. This delivery system utilizes both coated and uncoated nanoparticles for the effective delivery of methylene blue (MB). The PLGA-based polymer used in this system has been shown to be biocompatible and biodegradable. The synthesized nanoparticles are monodispersed, exhibit a slight negative charge, and fall within the optimal size range of 100-150 nm for intravenous delivery to the brain. Immunoblotting experiments indicate that GSH-coated NPs are more effective in reducing tau levels compared to MB solution, with in vitro BBB Transwell permeation studies showing an eight-fold increase in MB-NP permeation compared to the MB solution over 24 hours.
Career Highlights
Jinwal has worked with esteemed organizations such as the University of South Florida and the United States Government, represented by the Department of Veterans Affairs. His research has significantly advanced the understanding and application of nanoparticle technology in medical treatments.
Collaborations
Throughout his career, Jinwal has collaborated with notable colleagues, including Laurent Calcul and Bill J Baker. These partnerships have contributed to the success and impact of his innovative research.
Conclusion
Umesh Kumar Jinwal's work in nanoparticle delivery systems represents a significant advancement in the