The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2021
Filed:
Apr. 15, 2020
Applicant:
University of South Florida, Tampa, FL (US);
Inventors:
Vijaykumar Bhadabhai Sutariya, Tampa, FL (US);
Umesh Kumar Jinwal, Temple Terrace, FL (US);
Assignee:
UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 9/51 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4439 (2013.01); A61K 9/51 (2013.01); A61K 9/5123 (2013.01); A61K 9/5146 (2013.01); A61K 9/5153 (2013.01);
Abstract
Nanoparticle based MKT formulation. MKT is encapsulated by poly(ethylene glycol)ylated (PEGylated) poly-(lactide-co-glycolide) (PLGA) to form nanoparticles (NPs). To induce trans-BBB permeability, glutathione (GSH) is coated on the resulting NPs. Newly generated MKT-NPs showed BBB permeability and tau reduction in experimental models. Specifically, brain-targeting MKT NPs were developed with a glutathione coating, characterized, and shown to permeate BBB permeation insert models as a therapeutic for Alzheimer's disease and related tauopathies.