Ulf Stahl

Title: Ulf Stahl - Innovator in Neurotoxin Purification

Introduction

Ulf Stahl is a prominent inventor based in Uppsala, Sweden. He has made significant contributions to the field of neurotoxin purification, holding a total of 5 patents. His work focuses on developing methods that enhance the purity and stability of neurotoxin formulations, which are crucial for therapeutic applications.

Latest Patents

Stahl's latest patents include a method of purifying botulinum toxin. This technology relates to commercial-scale methods for purifying botulinum toxin compositions obtained from cell cultures. The purification methods are based on a series of filtration and chromatographic separation steps that produce a high-purity botulinum toxin composition. This composition comprises botulinum toxin protein molecules (˜150 kDa) in solution, which is free, essentially free, or substantially free of botulinum toxin complexes and animal products. Notably, the method does not involve precipitation, lyophilization, or centrifugation steps, allowing for the production of highly pure, highly active, free botulinum toxin protein molecules in solution.

Another significant patent involves a liquid neurotoxin formulation stabilized with tryptophan or tyrosine. This invention relates to stable liquid neurotoxin formulations that are free of animal proteins. These formulations include a surfactant, an amino acid selected from tryptophan and tyrosine, and a buffer comprising sodium, chloride, and phosphate ions. The formulations have a pH between 5.5 and 8 and are stable for two months, making them suitable for therapeutic use.

Career Highlights

Throughout his career, Ulf Stahl has worked with notable companies such as BASF Plant Science GmbH and Ipsen Biopharm Limited. His experience in these organizations has contributed to his expertise in the field of neurotoxin research and development.

Collaborations

Ulf has collaborated with several professionals in his field, including Marit Lenman and Antoni Banas. These collaborations have further enriched his research and innovation efforts.

Conclusion

Ulf Stahl is a distinguished inventor whose work in neurotoxin purification has led to significant advancements in the field. His innovative patents and collaborations highlight his commitment to improving therapeutic applications of neurotoxins.