The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 29, 2025

Filed:

Sep. 28, 2023
Applicant:

Ipsen Biopharm Limited, Wrexham, GB;

Inventors:

Anders Jarstad, Uppsala, SE;

Anna Friis, Uppsala, SE;

Ulf Stahl, Uppsala, SE;

Ann Gurell, Stockholm, SE;

Barbro Agren, Mattmar, SE;

Emilia Edstrom, Uppsala, SE;

Andrew Pickett, Uppsala, SE;

Assignee:

IPSEN BIOPHARM LIMITED, Wrexham, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/46 (2005.12); A61K 8/00 (2005.12); A61K 8/19 (2005.12); A61K 8/39 (2005.12); A61K 8/49 (2005.12); A61K 8/66 (2005.12); A61K 9/00 (2005.12); A61K 38/48 (2005.12); A61K 47/02 (2005.12); A61K 47/18 (2016.12); A61K 47/26 (2005.12); A61Q 19/08 (2005.12);
U.S. Cl.
CPC ...
A61K 38/4893 (2012.12); A61K 8/00 (2012.12); A61K 8/19 (2012.12); A61K 8/39 (2012.12); A61K 8/492 (2012.12); A61K 8/66 (2012.12); A61K 9/0019 (2012.12); A61K 47/02 (2012.12); A61K 47/183 (2012.12); A61K 47/26 (2012.12); A61Q 19/08 (2012.12);
Abstract

The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.


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