Tsung-Li Liu

Title: Innovations of Tsung-Li Liu

Introduction

Tsung-Li Liu is a prominent inventor based in San Diego, CA. He holds a total of four patents that showcase his contributions to the fields of nucleic acid nanostructures and advanced microscopy techniques. His work has significant implications for both scientific research and practical applications.

Latest Patents

One of his latest patents is titled "Compositions and methods for preparing nucleic acid nanostructures using compaction oligonucleotides." This patent describes methods for preparing immobilized nucleic acid nanostructures that utilize compaction oligonucleotides. The process involves rolling circle amplification reactions that generate concatemer molecules with multiple copies of a polynucleotide unit arranged in tandem. These nanostructures exhibit improved sequencing accuracy due to their compact and stable characteristics, which enhance signal intensity during sequencing cycles.

Another notable patent is "High-resolution, real-time imaging with adaptive optics and lattice light sheets." This invention involves a microscope that directs light through an excitation objective to create a lattice light sheet within a sample. The system collects signal light from the sample and modifies wavefronts to reduce sample-induced aberrations, thereby improving imaging quality.

Career Highlights

Throughout his career, Tsung-Li Liu has worked with prestigious institutions such as the Howard Hughes Medical Institute and Harvard College. His experience in these organizations has allowed him to collaborate with leading scientists and contribute to groundbreaking research.

Collaborations

Some of his notable coworkers include Daniel E Milkie and Kai Wang. Their collaborative efforts have further advanced the research and development of innovative technologies in their respective fields.

Conclusion

Tsung-Li Liu's contributions to the fields of nucleic acid nanostructures and advanced microscopy are significant. His patents reflect a commitment to innovation and excellence in scientific research.