Tsafi Pe'ery

Title: Tsafi Pe'ery: Innovator in mRNA Decay Research

Introduction

Tsafi Pe'ery is a notable inventor based in Montclair, NJ (US). He has made significant contributions to the field of molecular biology, particularly in the area of mRNA decay. With a total of 3 patents, his work focuses on innovative methods to treat various conditions related to nonsense-mediated decay (NMD).

Latest Patents

Pe'ery's latest patents include groundbreaking methods for inhibiting nonsense-mediated mRNA decay. One of his patents, titled "Inhibition of nonsense mediated mRNA decay by drugs that prevent hypusination of eukaryotic initiation factor 5A," provides methods for treating NMD by administering an inhibitor of NMD and a nonsense suppressor. This approach decreases the degradation of NMD susceptible mRNA and blocks translation termination at misplaced nonsense codons. Another patent, "Method of inhibiting nonsense-mediated mRNA decay," outlines a treatment method that involves administering a composition comprising an eIF5A inhibitor compound. This method effectively prevents intracellular hypusination of eIF5A, thereby increasing gene expression of NMD-susceptible mRNA.

Career Highlights

Tsafi Pe'ery is affiliated with Rutgers, The State University of New Jersey, where he conducts his research. His work has garnered attention for its potential applications in treating genetic disorders and other conditions related to mRNA decay.

Collaborations

Pe'ery has collaborated with esteemed colleagues, including Michael B Mathews and Hartmut M Hanauske-Abel. These collaborations have further enriched his research and contributed to advancements in the field.

Conclusion

In summary, Tsafi Pe'ery is a prominent inventor whose work in mRNA decay research has led to valuable patents and innovative treatment methods. His contributions continue to impact the scientific community and hold promise for future medical advancements.