Company Filing History:
Years Active: 2017-2023
Title: Innovations of Timothy Pabst
Introduction
Timothy Pabst is an accomplished inventor based in Gaithersburg, MD (US). He holds a total of 4 patents that contribute significantly to the field of biochemistry and protein purification. His work focuses on enhancing the stability and bioactivity of albumin-fusion proteins.
Latest Patents
One of his latest patents is a method of purifying albumin-fusion proteins. This invention aims to reduce the level of oxidation of susceptible amino acid residues. The method involves an affinity matrix chromatography step followed by an anion exchange chromatography step. The resulting purified albumin-fusion proteins exhibit low levels of oxidation, which helps retain their enhanced half-life in vivo and their bioactivity. In certain embodiments, the albumin-fusion protein may include a scaffold, such as the human Tenascin C scaffold. Compositions that incorporate the albumin-fusion protein are also disclosed in this patent.
Career Highlights
Throughout his career, Timothy Pabst has worked with notable companies, including MedImmune Limited. His contributions to the field have been recognized through his innovative approaches to protein purification.
Collaborations
Timothy has collaborated with esteemed colleagues such as Alan Hunter and Xiangyang Wang, further enhancing the impact of his work in the scientific community.
Conclusion
Timothy Pabst's innovations in the purification of albumin-fusion proteins demonstrate his commitment to advancing biochemistry. His patents reflect a deep understanding of protein stability and bioactivity, making significant contributions to the field.