The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2018
Filed:
Dec. 19, 2013
Applicant:
Medimmune, Llc, Gaithersburg, MD (US);
Inventors:
Alan Hunter, Gaithersburg, MD (US);
Thomas Linke, Gaithersburg, MD (US);
Timothy Pabst, Gaithersburg, MD (US);
Michaela Wendeler, Gaithersburg, MD (US);
Xiangyang Wang, Gaithersburg, MD (US);
Christopher Thompson, Gaithersburg, MD (US);
Guoling Xi, Gaithersburg, MD (US);
Andrew Fulton, Gaithersburg, MD (US);
Assignee:
MedImmune, LLC, Gaithersburg, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C07K 17/00 (2006.01); C07K 19/00 (2006.01); C07K 1/36 (2006.01); A61K 39/44 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 14/21 (2006.01); C07K 1/113 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2851 (2013.01); A61K 39/39591 (2013.01); C07K 1/1136 (2013.01); C07K 1/36 (2013.01); C07K 14/21 (2013.01); C07K 16/2803 (2013.01); C07K 16/30 (2013.01); C07K 2317/14 (2013.01); C07K 2317/56 (2013.01); C07K 2319/55 (2013.01);
Abstract
The present invention provides methods of preparing active immunoconjugates, including anti-CD22 immunoconjugates. Suitably, the methods include a fed-batch refolding process and/or column stripping process that result in an increase in yield of the immunoconjugate over other processes that do not utilize the methods.