The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Mar. 11, 2016
Medimmune, Llc, Gaithersburg, MD (US);
Timothy Pabst, Gaithersburg, MD (US);
Mariko Fonseca, Gaithersburg, MD (US);
Christopher Thompson, Gaithersburg, MD (US);
Alan Hunter, Gaithersburg, MD (US);
Xiangyang Wang, Gaithersburg, MD (US);
Liu Tie, Gaithersburg, MD (US);
Yiming Li, Gaithersburg, MD (US);
MedImmune, LLC, Gaithersburg, MD (US);
Abstract
The present invention relates to a method of purifying albumin-fusion proteins to reduce the level of oxidation of susceptible amino acid residues. The method comprises an affinity matrix chromatography step and an anion exchange chromatography step. The purified albumin-fusion proteins have low levels of oxidation and retain their enhanced half-life in vivo and its bioactivity. In some embodiments, the albumin-fusion protein comprises a scaffold, such as human Tenascin C scaffold. Compositions comprising the albumin-fusion protein are further disclosed.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile