This inventor holds 2 USPTO granted patents and 1 published patent application and 1 EPO patent. Top assignees: Medimmune Limited, Medlmmune Limited. Active years: 2020-2023.
Company Filing History:
Years Active: 2020-2023
Title: Mariko Fonseca: Innovator in Protein Purification
Introduction
Mariko Fonseca is a prominent inventor based in Gaithersburg, MD (US). She has made significant contributions to the field of protein purification, holding 2 patents that focus on enhancing the stability and bioactivity of albumin-fusion proteins. Her work is crucial for advancements in biopharmaceuticals and therapeutic applications.
Latest Patents
One of her latest patents is a method of purifying albumin-fusion proteins. This invention aims to reduce the level of oxidation of susceptible amino acid residues. The method involves an affinity matrix chromatography step followed by an anion exchange chromatography step. The resulting purified albumin-fusion proteins exhibit low levels of oxidation, which helps retain their enhanced half-life in vivo and their bioactivity. In some embodiments, the albumin-fusion protein includes a scaffold, such as the human Tenascin C scaffold. Additionally, compositions comprising the albumin-fusion protein are disclosed in her patent.
Career Highlights
Throughout her career, Mariko Fonseca has worked with notable companies, including MedImmune Limited. Her experience in these organizations has allowed her to develop her expertise in protein purification and biopharmaceuticals.
Collaborations
Mariko has collaborated with esteemed colleagues, including Timothy Pabst and Christopher D. Thompson. These partnerships have contributed to her innovative work and advancements in her field.
Conclusion
Mariko Fonseca is a trailblazer in the realm of protein purification, with her inventions paving the way for improved therapeutic applications. Her contributions are vital to the ongoing development of biopharmaceuticals and the enhancement of protein stability.