Company Filing History:
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1 out of 832,843 Years Active: 2018-2023
Title: Innovations of Tianfu Zhang in Biotechnology
Introduction
Tianfu Zhang is a prominent inventor based in Beijing, China, known for his significant contributions to the field of biotechnology. With a total of two patents to his name, Zhang has made strides in the development of innovative solutions for medical applications.
Latest Patents
One of Zhang's latest patents is the LRFFT2 cell, which utilizes human peripheral blood for ctDNA sequencing or tumor tissues for whole exome sequencing. This invention screens out mutation sites to perform antigen epitope prediction and synthesizes an expression gene sequence of mutant peptides. Additionally, it constructs a lentiviral vector, packages the lentivirus, and transfects an APC cell to complete the transformation of a specific LV cell. The invention also involves co-culturing in vitro with PBMC separated from peripheral blood to screen out effective polypeptides and transform common T cells into RFF cells. The suppressive signaling molecules identified include PD-1, Tim-3, LAG3, CTLA-4, BTLA, VISTA, CD160, and 2B4 (CD244). Antigen presenting cells include PBMC, dendritic cells, neutrophils, B lymphocytes, and macrophages.
Another notable patent focuses on non-coding RNA and its identification and application. This invention demonstrates that a bacterium can deliver non-coding RNAs (ncRNAs) encoded by itself into a host cell. It generates milRNAs similar to microRNAs through a microRNA splicing system in the cell, regulating the immune system with these milRNAs and protecting the bacterium from being cleared by the host. The invention also provides methods for effective detection, treatment, and study of bacteria or infectious diseases.
Career Highlights
Zhang has worked with notable companies such as Jiangsu Micromedmark Biotech Co., Ltd. and Beijing Dcty Biotech Co., Ltd. His work in these organizations has contributed to advancements in biotechnology and medical research.
Collaborations
Zhang has collaborated with esteemed colleagues, including Ke Zeng and Hongwei Gu, further enhancing his research and innovation efforts.
Conclusion
Tianfu Zhang's contributions to biotechnology through his patents and collaborations highlight his role as an influential inventor in the field. His work continues to pave the way for advancements in medical technology and research.