The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2018
Filed:
Dec. 09, 2014
Jiangsu Micromedmark Biotech Co. Ltd., Jiangsu, CN;
Ke Zeng, Beijing, CN;
Hongwei Gu, Beijing, CN;
Chenyu Zhang, Beijing, CN;
Tianfu Zhang, Beijing, CN;
JIANGSU MICROMEDMARK BIOTECH CO., LTD., Taizhou, Jiangsu, CN;
Abstract
The present invention providesnon-coding RNA and the identification and application thereof. In particular, the present invention proves through experiments that abacterium delivers non-coding RNAs (ncRNAs) encoded by the bacterium itself into a host cell, generates milRNAs similar to microRNAs by means of a microRNA splicing system in the cell, regulates the immune system with the milRNAs, and further protects thebacterium from being cleared by the host. Adsorbing milRNAs using milRNA inhibitors can effectively inhibit the survival ability of the bacterium in the cell, leading to a reduced vitality of the bacterium. The present invention further provides relevant reagents and methods for effective detection of, treatment to and study onbacteria orinfectious diseases.