Company Filing History:
2 out of 410 
2 out of 7 
1 out of 2 Years Active: 1994-2006
Title: Thomas R Van Oosbree: Innovator in Protein Synthesis
Introduction
Thomas R Van Oosbree is a notable inventor based in Madison, WI (US). He has made significant contributions to the field of protein synthesis, holding a total of 5 patents. His work has paved the way for advancements in biotechnology and molecular biology.
Latest Patents
One of his latest patents involves an E. coli extract for protein synthesis. This innovation has led to the development of kits that contain the necessary components for performing protein synthesis reactions using the experimenter's template DNA. The patent discloses a simple fractionation process that can dramatically enhance the performance of an S-30 prokaryotic protein synthesis reaction mixture. This process includes freezing and thawing the S-30 extract, combined with a supplemental mix, followed by centrifugation. The resulting fractionated S-30 reaction mixture yields more full-length target protein and less non-full length or non-target protein compared to prior art S-30 systems. Another significant patent is a method for in vitro protein synthesis. This method describes a coupled in vitro transcription and translation reaction, where the quantity of mRNA produced is limited to less than about 2.5 micrograms in a 10 microliter volume prior to the addition of translation elements. This limitation prevents saturation of the translational processes, thereby enhancing the efficiency and fidelity of the translation process.
Career Highlights
Throughout his career, Thomas has worked with prominent companies in the biotechnology sector, including Promega Corporation and Novagen, Inc. His experience in these organizations has contributed to his expertise in protein synthesis and molecular biology.
Collaborations
Thomas has collaborated with notable colleagues such as Robert C Mierendorf and David V Thompson. These partnerships have further enriched his work and innovations in the field.
Conclusion
Thomas R Van Oosbree is a distinguished inventor whose contributions to protein synthesis have had a lasting impact on biotechnology. His innovative patents and collaborations highlight his commitment to advancing scientific knowledge and technology.