Company Filing History:
Years Active: 1998-2017
Title: Innovations of Thomas G. Wood in DNA Aptamers
Introduction
Thomas G. Wood is an accomplished inventor based in Houston, TX (US). He has made significant contributions to the field of biotechnology, particularly in the development of DNA aptamers. With a total of 5 patents, his work focuses on creating high-affinity ligands that can bind to specific protein targets, which has important implications for therapeutic applications.
Latest Patents
One of his latest patents involves the creation of single-stranded DNA aptamers that bind to NF-kB/RelA. These DNA aptamers are chemically stable and reproducible molecules that can serve as affinity reagents or therapeutic drugs. NF-kB is a crucial mediator of the innate immune response and plays a significant role in tissue inflammation. This invention marks the first identification of single-stranded DNA aptamers that specifically recognize NF-kB RelA. The aptamers can bind to various distinct regions of RelA, potentially serving multiple purposes, such as antagonizing the DNA binding of RelA to inhibit cellular inflammation, visualizing the location or amount of RelA in tissues affected by pathological conditions, or quantitatively measuring the activated state of RelA through affinity binding.
Career Highlights
Thomas G. Wood is affiliated with the University of Texas System, where he continues to advance research in the field of biotechnology. His innovative work has garnered attention and respect within the scientific community, contributing to the understanding of immune responses and inflammation.
Collaborations
Some of his notable coworkers include Allan R. Brasier and Pomila Singh, who have collaborated with him on various research projects related to DNA aptamers and their applications.
Conclusion
Thomas G. Wood's contributions to the field of biotechnology, particularly through his patents on DNA aptamers, highlight his role as a leading inventor in this area. His work not only enhances our understanding of immune responses but also opens new avenues for therapeutic interventions.
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