Thierry Bettinger

Title: Thierry Bettinger: Innovator in Recombinant Protein Technology

Introduction

Thierry Bettinger is a notable inventor based in Peillonnex, France. He has made significant contributions to the field of biotechnology, particularly in the development of recombinant proteins. With a total of seven patents to his name, Bettinger has established himself as a key figure in innovative protein engineering.

Latest Patents

One of Thierry Bettinger's latest patents is focused on a recombinant chimeric protein designed for selectins targeting. This invention discloses a protein known as PSGL-1-NRL, which comprises a Selectin Binding domain and a non-covalent dimerization domain, specifically a leucine zipper. The chimeric protein also includes a covalent dimerization domain with at least one cysteine, allowing it to form a disulfide bridge with another chimeric protein to create a homodimer. The PSGL-1 domain corresponds to the extracellular region of Human PSGL-1, particularly the selectin binding region of the mature protein. This innovative protein is efficiently expressed in a mammalian system and is correctly post-translationally modified. It is sulfated, O-linked glycosylated, and sialylated, enabling it to bind P, E, and L selectin. This functionality allows for in vivo and in vitro targeting for diagnostic or therapeutic purposes.

Career Highlights

Throughout his career, Thierry Bettinger has worked with prominent companies in the biotechnology sector, including Bracco Suisse and Bracco Suisse SA. His work has focused on advancing the understanding and application of recombinant proteins in medical and therapeutic contexts.

Collaborations

Some of his notable coworkers include Philippe Bussat and Samir Cherkaoui, who have collaborated with him on various projects in the field of biotechnology.

Conclusion

Thierry Bettinger is a distinguished inventor whose work in recombinant protein technology has the potential to impact diagnostic and therapeutic applications significantly. His innovative contributions continue to advance the field and inspire future research.