Steven Francis Josephs

Title: The Innovative Contributions of Steven Francis Josephs

Introduction

Steven Francis Josephs is a notable inventor based in San Diego, California. He has made significant contributions to the field of biomedical engineering, particularly in the development of methods and devices aimed at enhancing therapeutic responses in cancer treatment. With a total of six patents to his name, Josephs has demonstrated a commitment to innovation and improvement in medical technologies.

Latest Patents

Among his latest patents, one notable invention is the "Modified TNF as a capture ligand." This patent describes a column designed for the removal of sTNF-R2 from body fluids. The column features a compartment with an inlet for receiving body fluid and a substrate within the compartment. A capture ligand, modified with an amino acid substitution in a reference sequence that includes a portion of a natural TNF sequence, is coupled to the substrate. This modified sequence exhibits a greater affinity for sTNF-R2 compared to the reference sequence.

Another significant patent is titled "Increasing responses to checkpoint inhibitors by extracorporeal apheresis." This invention outlines methods and compositions that enhance tumor responses to checkpoint inhibitors. It emphasizes the use of extracorporeal apheresis to remove immunological blocking factors derived from tumors or their microenvironments. Specifically, the removal of soluble TNF-alpha receptors (sTNF-Rs) is highlighted as a means to augment the efficacy of immune checkpoint inhibitors, particularly those targeting the PD-1/PD-L1 and CD28/CTLA-4 pathways.

Career Highlights

Throughout his career, Steven Josephs has worked with prominent organizations such as Immunicom, Inc. and the National Institutes of Health, a component of the US Department of Health & Human Services. His work in these institutions has allowed him to collaborate on groundbreaking research and development projects that aim to improve patient outcomes in cancer therapy.

Collaborations

Josephs has collaborated with notable colleagues, including Amir Jafri and Stephen Michael Prince. These partnerships have contributed to the advancement of his research and the successful development of his patented technologies.

Conclusion

Steven Francis Josephs is a distinguished inventor whose work has significantly impacted the field of biomedical engineering. His innovative patents and collaborations reflect his dedication to improving cancer treatment methodologies. Through his contributions, Josephs continues to pave the way for advancements in medical technology.