The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2024
Filed:
Jun. 17, 2022
Applicant:
Immunicom, Inc., San Diego, CA (US);
Inventors:
Michael Matho, San Diego, CA (US);
Steven F. Josephs, San Diego, CA (US);
Annette Marleau, San Diego, CA (US);
Assignee:
IMMUNICOM INC., San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61M 1/36 (2006.01); A61K 39/39 (2006.01); A61K 39/395 (2006.01); B01D 15/38 (2006.01); C07K 14/525 (2006.01); C07K 14/555 (2006.01); C07K 14/70 (2006.01); C07K 14/705 (2006.01); G01N 33/543 (2006.01); A61M 1/34 (2006.01);
U.S. Cl.
CPC ...
A61M 1/362 (2014.02); A61K 39/395 (2013.01); A61K 39/39516 (2013.01); A61K 39/39525 (2013.01); B01D 15/3809 (2013.01); B01D 15/3828 (2013.01); C07K 14/525 (2013.01); C07K 14/555 (2013.01); C07K 14/70575 (2013.01); G01N 33/543 (2013.01); G01N 33/54353 (2013.01); A61M 1/3496 (2013.01);
Abstract
A column is disclosed for removal of sTNF-R2 from a body fluid. The column has a compartment, an inlet coupled to the compartment and configured to receive the body fluid, and a substrate disposed within the compartment. A capture ligand is coupled to the substrate and has a modified sequence with an amino acid substitution in a reference sequence that includes a portion of a natural TNF sequence. The modified sequence has an affinity for the sTNF-R2 that is greater than an affinity of the reference sequence for the sTNF-R2.