Steven Charles Defina is a notable inventor based in Burlingame, California. He has made significant contributions to the field of biotechnology, particularly in the development of compounds that modulate protein kinase activity. With a total of eight patents to his name, Defina's work has the potential to impact various medical applications.

Latest Patents

One of his latest patents is titled "Raf modulators and methods of use." This invention relates to compounds that modulate protein kinase enzymatic activity, influencing cellular activities such as proliferation, differentiation, programmed cell death, migration, and chemoinvasion. The compounds specifically target kinases, particularly Raf, and include methods for their use in treating kinase-dependent diseases. Another significant patent is "Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture." This invention encompasses compounds and their pharmaceutically acceptable salts or solvates, along with methods for making and using these compounds.

Career Highlights

Steven Charles Defina is currently associated with Exelixis, Inc., a company known for its focus on developing innovative cancer therapies. His work at Exelixis has allowed him to contribute to groundbreaking research in the field of oncology.

Collaborations

Throughout his career, Defina has collaborated with esteemed colleagues, including Neel Kumar Anand and Charles M Blazey. These collaborations have further enriched his research and development efforts.

Conclusion

Steven Charles Defina's contributions to biotechnology through his patents and work at Exelixis, Inc. highlight his role as an influential inventor in the field. His innovative approaches to modulating protein kinase activity have the potential to lead to significant advancements in medical treatments.

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