The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2011
Filed:
Apr. 22, 2005
Neel K. Anand, Burlingame, CA (US);
Charles M. Blazey, San Francisco, CA (US);
Owen Joseph Bowles, Pacifica, CA (US);
Joerg Bussenius, Foster City, CA (US);
Lynne Canne Bannen, Pacifica, CA (US);
Diva Sze-ming Chan, San Francisco, CA (US);
Baili Chen, Palo Alto, CA (US);
Erick Wang CO, San Diego, CA (US);
Simona Costanzo, Los Altos, CA (US);
Steven Charles Defina, Burlingame, CA (US);
Larisa Dubenko, San Francisco, CA (US);
Maurizio Franzini, San Francisco, CA (US);
Ping Huang, Mountain View, CA (US);
Vasu Jammalamadaka, Pleasonton, CA (US);
Richard George Khoury, Redwood City, CA (US);
Moon Hwan Kim, Palo Alto, CA (US);
Rhett Ronald Klein, Chicago, IL (US);
Donna Tra Le, San Jose, CA (US);
Morrison B. Mac, San Francisco, CA (US);
John M. Nuss, Danville, CA (US);
Jason Jevious Parks, Sacramento, CA (US);
Kenneth D. Rice, San Rafael, CA (US);
Tsze H. Tsang, El Cerrito, CA (US);
Amy Lew Tsuhako, Milpitas, CA (US);
Yong Wang, Foster City, CA (US);
Wei Xu, Danville, CA (US);
Neel K. Anand, Burlingame, CA (US);
Charles M. Blazey, San Francisco, CA (US);
Owen Joseph Bowles, Pacifica, CA (US);
Joerg Bussenius, Foster City, CA (US);
Lynne Canne Bannen, Pacifica, CA (US);
Diva Sze-Ming Chan, San Francisco, CA (US);
Baili Chen, Palo Alto, CA (US);
Erick Wang Co, San Diego, CA (US);
Simona Costanzo, Los Altos, CA (US);
Steven Charles Defina, Burlingame, CA (US);
Larisa Dubenko, San Francisco, CA (US);
Maurizio Franzini, San Francisco, CA (US);
Ping Huang, Mountain View, CA (US);
Vasu Jammalamadaka, Pleasonton, CA (US);
Richard George Khoury, Redwood City, CA (US);
Moon Hwan Kim, Palo Alto, CA (US);
Rhett Ronald Klein, Chicago, IL (US);
Donna Tra Le, San Jose, CA (US);
Morrison B. Mac, San Francisco, CA (US);
John M. Nuss, Danville, CA (US);
Jason Jevious Parks, Sacramento, CA (US);
Kenneth D. Rice, San Rafael, CA (US);
Tsze H. Tsang, El Cerrito, CA (US);
Amy Lew Tsuhako, Milpitas, CA (US);
Yong Wang, Foster City, CA (US);
Wei Xu, Danville, CA (US);
Exelixis, Inc., South San Francisco, CA (US);
Abstract
The present invention relates to compounds of the Formula (I) and (II) wherein R, R, R-R, m, n, X-X, and Qare defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.