The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2010
Filed:
Mar. 25, 2005
Neel Kumar Anand, Burlingame, CA (US);
Charles M. Blazey, San Francisco, CA (US);
Owen Joseph Bowles, Pacifica, CA (US);
Joerg Bussenius, Foster City, CA (US);
Simona Costanzo, Los Altos, CA (US);
Jeffry Kimo Curtis, San Anselmo, CA (US);
Larisa Dubenko, San Francisco, CA (US);
Abigail R. Kennedy, Oakland, CA (US);
Steven Charles Defina, Burlingame, CA (US);
Angie I. Kim, San Mateo, CA (US);
Jean-claire L. Manalo, Daly City, CA (US);
Csaba J. Peto, Alameda, CA (US);
Kenneth D. Rice, San Rafael, CA (US);
Tsze H. Tsang, El Cerrito, CA (US);
Anagha Abhijit Joshi, Fremont, CA (US);
Neel Kumar Anand, Burlingame, CA (US);
Charles M. Blazey, San Francisco, CA (US);
Owen Joseph Bowles, Pacifica, CA (US);
Joerg Bussenius, Foster City, CA (US);
Simona Costanzo, Los Altos, CA (US);
Jeffry Kimo Curtis, San Anselmo, CA (US);
Larisa Dubenko, San Francisco, CA (US);
Abigail R. Kennedy, Oakland, CA (US);
Steven Charles Defina, Burlingame, CA (US);
Angie I. Kim, San Mateo, CA (US);
Jean-Claire L. Manalo, Daly City, CA (US);
Csaba J. Peto, Alameda, CA (US);
Kenneth D. Rice, San Rafael, CA (US);
Tsze H. Tsang, El Cerrito, CA (US);
Anagha Abhijit Joshi, Fremont, CA (US);
Exelixis, Inc., South San Francisco, CA (US);
Abstract
The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.