Stephen S Rich

Title: The Innovations of Stephen S. Rich

Introduction

Stephen S. Rich is a notable inventor based in Saint Paul, MN (US). He has made significant contributions to the field of genetics, particularly in the area of HLA typing methods. With a total of 5 patents to his name, Rich's work has advanced the understanding of genetic polymorphisms and their applications in medical science.

Latest Patents

One of his latest patents is a DNA sequence-based HLA typing method. This invention provides a process for determining genotypes in highly polymorphic systems through polymerase chain reaction amplification of cDNA or genomic DNA. The method allows for the unambiguous determination of Class II and Class I HLA genotypes in any subject within 16-24 hours. This is achieved by direct sequencing of various transcripts that are enzymatically amplified using a limited number of non-allele-specific oligonucleotides. The process involves reverse transcription of total cellular RNA from peripheral blood mononuclear cells, followed by enzymatic amplification and direct sequencing of synthesized cDNA molecules.

Career Highlights

Stephen S. Rich is affiliated with the University of Minnesota, where he continues to contribute to research and innovation in genetics. His work has not only advanced scientific knowledge but has also paved the way for practical applications in medical diagnostics and treatment.

Collaborations

Rich has collaborated with notable colleagues such as Pedro Santamaria and Michael T. Boyce-Jacino. These partnerships have further enriched his research and expanded the impact of his inventions.

Conclusion

Stephen S. Rich's contributions to the field of genetics through his innovative patents highlight the importance of research in understanding complex genetic systems. His work continues to influence the medical field and improve diagnostic methods.