Shoujun Xu

Title: Shoujun Xu: Innovator in Super-Resolution Force Spectroscopy

Introduction

Shoujun Xu is a prominent inventor based in Houston, TX (US), known for his significant contributions to the field of super-resolution force spectroscopy. With a total of 11 patents to his name, Xu has developed innovative methods that enhance the understanding of biomolecular interactions.

Latest Patents

Xu's latest patents include groundbreaking technologies such as "Multiplexable super-resolution force spectroscopy using ultrasound methods and magnetic detection." This method allows for the measurement of dissociation of biomolecular bonds in one or multiple sample wells using super-resolution force spectroscopy (SURFS). SURFS employs precise ultrasound radiation to exert an acoustic radiation force on biomolecular bonds labeled with magnetic particles. The force-induced dissociation of these protein bonds can be measured as a reduced magnetic signal by a magnetic sensor. This technology enables the differentiation of biomolecular bonds with an extremely high level of precision, including interactions among protein-protein, protein-nucleic acid, nucleic acid-nucleic acid, small molecule-protein, and small molecule-nucleic acid.

Another notable patent is "Force-modulated hybridization for visualizing nucleic acid length and function." This patent pertains to methods that utilize force-modulated hybridization to determine the length of an analyte strand, identify an unknown nucleic acid sequence, or assess the binding of a nucleotide to an active agent. The patent also includes sample holder devices and detection devices that enhance the functionality of these methods.

Career Highlights

Shoujun Xu has had a distinguished career, working with esteemed institutions such as the University of Houston System and the University of California. His work has significantly advanced the field of biomolecular research and has implications for various applications in biotechnology and medicine.

Collaborations

Throughout his career, Xu has collaborated with notable scientists, including Dmitry Budker and Alexander Pines. These collaborations have further enriched his research and contributed to the development of innovative technologies in his field.

Conclusion

Shoujun Xu's contributions to super-resolution force spectroscopy and biomolecular research have established him as a leading inventor in his field. His innovative patents and collaborations continue to push the boundaries of scientific understanding and application.