Location History:
- Brookline, MA (US) (2015)
- Arlington, MA (US) (2015)
Company Filing History:
Years Active: 2015
Title: Innovations by Sharon D Wilhelm
Introduction
Sharon D Wilhelm is a prominent inventor based in Brookline, MA (US). She has made significant contributions to the field of drug development, particularly in creating innovative conjugates that enhance the efficacy of cancer treatments. With a total of 2 patents, her work has the potential to revolutionize therapeutic approaches in oncology.
Latest Patents
One of her latest patents focuses on potent conjugates and hydrophilic linkers. These linkers are designed to bind drugs to cell-binding agents, modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. This modification surprisingly enhances the potency and efficacy of the cell-binding agent-drug conjugates across various cancer cell types, including those with low antigen expression or resistance to treatment. Another significant patent involves a method for preparing maytansinoids that bear a thioether moiety and a reactive group, allowing for a streamlined linkage to a cell-binding agent in a single step. Additionally, she has developed cytotoxic agents comprising new ansamitocin derivatives, which are linked to cell-binding agents, demonstrating vastly improved therapeutic efficacy in animal tumor models compared to previously described agents.
Career Highlights
Sharon D Wilhelm is currently associated with Immunogen, Inc., where she continues to innovate in the field of targeted cancer therapies. Her work is characterized by a commitment to improving treatment outcomes for patients suffering from various forms of cancer.
Collaborations
Throughout her career, Sharon has collaborated with notable colleagues, including Ravi V J Chari and Rajeeva Singh. These partnerships have further enhanced her research and development efforts in the pharmaceutical industry.
Conclusion
Sharon D Wilhelm's contributions to drug development and cancer treatment exemplify the impact of innovative thinking in the medical field. Her patents and ongoing work at Immunogen, Inc. highlight her dedication to advancing therapeutic options for patients.