The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
Nov. 03, 2011
Ravi V. J. Chari, Newton, MA (US);
Wayne C. Widdison, Belmont, MA (US);
Sharon D. Wilhelm, Arlington, MA (US);
Ravi V. J. Chari, Newton, MA (US);
Wayne C. Widdison, Belmont, MA (US);
Sharon D. Wilhelm, Arlington, MA (US);
ImmunoGen, Inc., Waltham, MA (US);
Abstract
New ansamitocin derivatives bearing a linking group are disclosed. Also disclosed are methods for the synthesis of these new ansamitocin derivatives and methods for their linkage to cell-binding agents. The ansamitocin derivative-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.