The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2015
Filed:
Oct. 06, 2009
Rajeeva Singh, Framingham, MA (US);
Yelena Kovtun, Stow, MA (US);
Sharon D. Wilhelm, Brookline, MA (US);
Ravi V. J. Chari, Newton, MA (US);
Rajeeva Singh, Framingham, MA (US);
Yelena Kovtun, Stow, MA (US);
Sharon D. Wilhelm, Brookline, MA (US);
Ravi V. J. Chari, Newton, MA (US);
ImmunoGen, Inc., Waltham, MA (US);
Abstract
Linkers for binding drugs to cell binding agents are modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. The potency or the efficacy of the cell-binding agent-drug conjugates is surprisingly enhanced several folds in a variety of cancer cell types, including those expressing a low number of antigens on the cell surface or cancer cells that are resistant to treatment. A method for preparing maytansinoids bearing a thioether moiety and a reactive group which allows the maytansinoid to be linked to a cell-binding agent in essentially a single step is also provided.