Saran A Narang

Title: Saran A Narang: Innovator in Brain-Targeting Antibody Fragments

Introduction

Saran A Narang is a prominent inventor based in Ottawa, Canada. He has made significant contributions to the field of biotechnology, particularly in the development of brain-targeting antibody fragments. With a total of 11 patents to his name, Narang's work is paving the way for advancements in drug delivery systems.

Latest Patents

One of Narang's latest patents involves the creation of single domain brain-targeting antibody fragments derived from llama antibodies. This innovation includes a phage-displayed library of llama single heavy domain antibodies (sdAbs) that have been enriched to selectively bind to and be internalized by human cerebromicrovascular endothelial cells (HCEC). From this enriched library, two sdAbs were selected, sequenced, subcloned, and expressed as fusion proteins with c-myc-Histags. These soluble tagged sdAbs demonstrated the ability to selectively bind to HCEC and to transmigrate across an in vitro human blood-brain barrier (BBB) model. Notably, these sdAbs were detected in the brain after intravenous injection into mice, showcasing their potential as brain-specific delivery vectors for facilitating drug transport across the BBB.

Career Highlights

Throughout his career, Saran A Narang has worked with esteemed organizations such as the National Research Council of Canada and Cornell Research Foundation Inc. His innovative research has garnered attention and respect within the scientific community.

Collaborations

Narang has collaborated with notable colleagues, including Jamshid Tanha and Ray J Wu, contributing to the advancement of his research and innovations.

Conclusion

Saran A Narang's work in developing brain-targeting antibody fragments represents a significant leap forward in biotechnology. His contributions are essential for improving drug delivery systems, which could have a profound impact on medical treatments in the future.