Sarah Shuck

Title: **Innovator Spotlight: Sarah Shuck from Orange, CA**

Introduction

Sarah Shuck, an accomplished inventor based in Orange, California, has made significant contributions to medical research with her innovative approach to understanding metabolic disorders. With two patents under her name, she is recognized for her groundbreaking work in quantifying specific nucleic acid adducts linked to serious health conditions.

Latest Patents

Her latest patents include methods for quantifying methylglyoxal-induced nucleic acid adducts. These techniques focus on measuring N-(1-carboxyethyl)-2'-deoxyguanosine (CEdG) and N-(1-carboxyethyl)-guanosine (CEG) levels in biological samples. By comparing these levels to known normal benchmarks, her research can help diagnose various metabolic disorders such as diabetes and certain types of cancer. Additionally, these methods can evaluate the effectiveness of therapies by measuring changes in CEdG and CEG levels before and after treatment, utilizing advanced techniques like liquid chromatography electrospray ionization tandem mass spectrometry.

Another of her notable patents is related to recombinant lectins and their applications. This invention involves a recombinant S27S5 hemagglutinin (SHA) and its homologues, along with a fusion protein that incorporates a fluorescent protein such as GFP or mCherry. These proteins are designed to specifically bind to carbohydrates, enabling the detection of various microorganisms and cancer antigens, thereby advancing the field of cancer research.

Career Highlights

Sarah is currently affiliated with City of Hope, a prominent research and treatment center. Her role has allowed her to engage deeply in scientific innovation while contributing positively to the healthcare sector.

Collaborations

Throughout her career, Sarah has collaborated with esteemed colleagues, including Markus Kalkum and Yoko Fujita-Yamaguchi. These partnerships have facilitated the exchange of ideas and have been instrumental in propelling her innovative projects forward.

Conclusion

As a dedicated inventor, Sarah Shuck exemplifies the spirit of innovation in the medical field. Her patents highlight her commitment to developing methods that can potentially save lives and improve patient outcomes. With her continued efforts, she remains a vital contributor to the ongoing research and understanding of metabolic disorders and cancer diagnostics.