City of Hope

Sarah Shuck

Markus Kalkum

Karine Bagramyan

Teresa B Hong

John Termini

Timothy W Synold

Yoko Fujita-Yamaguchi

Methods of quantifying a N-(1-carboxyethyl)-2'-deoxyguanosine (CEdG) and N-(1-carboxyethyl)-guanosine (CEG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG and CEG levels before and after treatment. Measurement of CEdG and CEG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.

Methods of quantifying methylglyoxal-induced nucleic acid adducts

Disclosed herein are a recombinantS27S5 hemagglutinin (SHA), and homologues thereof, and a fusion protein of a fluorescent protein (such as GFP and mCherry1) and SHA or a homologue thereof, which specifically bind to carbohydrates, including oligomeric sugars that terminate in L-rhamnose or D-galactose. The SHA, SHA homologues, and fusion proteins can be used to detect a variety of microorganisms or cancer or tumor antigens.

Recombinant lectin and uses thereof

Growing community of inventors

Orange, CA, United States of America

Sarah Shuck