Location History:
- Nishitokyo, JP (2017)
- Koganei, JP (2021)
Company Filing History:
Years Active: 2017-2021
Title: The Innovations of Sadaharu Higuchi
Introduction
Sadaharu Higuchi is a prominent inventor based in Nishitokyo, Japan. He has made significant contributions to the field of biotechnology, particularly in the development of innovative therapeutic agents. With a total of 3 patents to his name, Higuchi's work focuses on advancing medical treatments through cutting-edge research.
Latest Patents
Higuchi's latest patents include groundbreaking inventions that address critical challenges in medicine. One of his notable patents is for a chemically-modified siRNA. The objective of this invention is to provide a chemically-modified siRNA that has polydeoxyadenylic acid added to the 5' end of the sense strand. This siRNA, when complexed with schizophyllan, demonstrates high resistance against RNase and effectively exhibits RNAi activity. Specific chemical modifications are performed on dinucleotide sequences within the base sequence to enhance its efficacy.
Another significant patent is for an immune tolerance inducer. This invention aims to provide a drug and method for effectively inducing donor-specific immune tolerance in recipients undergoing transplantation therapy. By delivering a complex of siRNA for a costimulatory factor and schizophyllan to Dectin-1 expressing cells, this method regulates cell function and induces immunosuppression, thereby promoting immune tolerance.
Career Highlights
Sadaharu Higuchi is currently associated with Napajen Pharma, Inc., where he continues to innovate and develop new therapeutic solutions. His work has garnered attention in the scientific community, contributing to advancements in the field of immunology and RNA therapeutics.
Collaborations
Higuchi collaborates with esteemed colleagues, including Hironori Ando and Ko Rii. Their combined expertise fosters a dynamic research environment that enhances the potential for groundbreaking discoveries.
Conclusion
Sadaharu Higuchi's contributions to biotechnology through his innovative patents reflect his commitment to advancing medical science. His work not only addresses current medical challenges but also paves the way for future developments in therapeutic treatments.