Russell Frost

Title: The Innovative Contributions of Russell Frost

Introduction

Russell Frost, an accomplished inventor based in Concord, CA, has significantly impacted the field of chromatography with his innovative methods. With a total of six patents under his name, Frost has demonstrated a commitment to advancing protein purification techniques, making remarkable strides in the scientific community.

Latest Patents

Among Frost's notable contributions is his recent patent titled "Solid Phase for Mixed-Mode Chromatographic Purification of Proteins." This patent outlines a method for manufacturing a mixed-mode chromatography medium that involves oxidizing diol groups on diol-functionalized solid particles. These particles are characterized by having a median pore diameter of 0.5 microns or greater and a diol density between 200 to 300 µmol/mL. This innovative process converts diol-functionalized solid particles into aldehyde-functionalized counterparts that can efficiently couple with amine-functionalized ligands, featuring an amine-substituted hydrophobic group linked to an acid moiety.

Another critical patent in his portfolio emphasizes the purification of proteins through a mixed-mode chromatography system. This system is established by attaching a ligand that comprises benzamidoacetic acid to a large-pore support matrix. Crucially, the only linkage between the ligand and the support matrix is a chain with a maximum backbone of three atoms between a phenyl ring and the support matrix.

Career Highlights

Russell Frost has honed his skills at notable institutions, including Bio-Rad Laboratories, Inc. and Rensselaer Polytechnic Institute. His experiences in these organizations have significantly enriched his knowledge and expertise, allowing him to pioneer advancements in chromatography.

Collaborations

Throughout his career, Frost has collaborated with talented individuals in the industry, including Jiali Liao and Hong Chen. These partnerships reflect the importance of teamwork in scientific research and innovation, facilitating the exchange of ideas that lead to groundbreaking patents.

Conclusion

Russell Frost's contributions to the field of chromatography, particularly in protein purification methods, showcase his role as a leading inventor. His innovative patents and career experiences reflect his dedication to advancing scientific understanding and practice, making notable strides in the realm of biochemistry. As he continues to explore new avenues of research, his work will undoubtedly inspire future generations of inventors in the field.