The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2017
Filed:
Mar. 05, 2013
Jiali Liao, San Ramon, CA (US);
Russell Frost, Concord, CA (US);
Jiali Liao, San Ramon, CA (US);
Russell Frost, Concord, CA (US);
Bio-Rad Laboratories, Inc., Hercules, CA (US);
Abstract
Solid supports and ligands are provided for purification of biomolecules by mixed-mode anion exchange-hydrophobic chromatography. Compositions can have the formula Support-(X)—N(R, R)—R-L-Ar, or a salt thereof, wherein: Support is a chromatographic solid support; X is a spacer or absent; Rand Rare each selected from hydrogen and an alkyl comprising 1-6 carbons; Ris an alkyl comprising 1-6 carbons or a cyclo alkyl comprising 1-6 carbons; L is NR, O, or S; wherein Ris hydrogen or an alkyl comprising 1-6 carbons; and Ar is an aryl. Methods are also provided for using solid supports and ligands to purify biomolecules such as monomeric antibodies.