Company Filing History:
Years Active: 2009-2024
Title: The Innovations of Ronald William Kriz
Introduction
Ronald William Kriz, an accomplished inventor based in Northborough, MA, has made significant contributions to the field of biotechnology. With five patents to his name, his work particularly focuses on antibody-drug conjugation, which plays a crucial role in targeted therapy for various diseases.
Latest Patents
Among his latest patents, Kriz has developed innovative methods involving capped and uncapped antibody cysteines. His patented processes in mammalian cells include engineering unpaired cysteine residues that are post-translationally modified and capped with specific chemical entities. These capped antibodies are specifically designed for site-specific conjugation to form antibody-drug conjugates (ADCs) or protein drug conjugates. The ADCs produced via these methods employ selective reduction of the cysteine residues and utilize biorthogonal groups like aldehyde, azide, and alkyne, allowing for further drug conjugation chemistry. Additionally, the process also addresses the production of uncapped antibodies in low cysteine and glutathione media.
Career Highlights
Throughout his career, Ronald Kriz has held significant roles in prominent companies, including Pfizer Corporation and Wyeth. His extensive knowledge and innovative approaches have positioned him as a notable figure in the biotech arena, particularly focusing on enhancing therapeutic options for patients through advanced antibody technologies.
Collaborations
Kriz has collaborated with talented professionals in the field, such as Xiaotian Zhong and Amarnauth Shastrie Prashad. These collaborations highlight the importance of teamwork in advancing scientific research and the development of groundbreaking technologies.
Conclusion
Ronald William Kriz continues to push the boundaries of innovation in biotechnology through his patent work and groundbreaking research. His contributions to antibody-drug conjugation are paving the way for more effective treatments, thereby positively impacting the pharmaceutical landscape. With ongoing advancements, Kriz remains a prominent inventor whose work is essential in the ever-evolving realm of therapeutic development.