The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2019
Filed:
Nov. 25, 2013
Applicant:
Pfizer Inc., New York, NY (US);
Inventors:
Tetsuya Ishino, Izumo, JP;
Weili Duan, North Reading, MA (US);
Ronald William Kriz, Northborough, MA (US);
Assignee:
Pfizer Inc., New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/00 (2006.01); C07K 16/00 (2006.01); C12P 21/08 (2006.01); C07H 21/04 (2006.01); C12P 21/06 (2006.01); C12P 21/04 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/00 (2013.01); C07K 2299/00 (2013.01); C07K 2317/41 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/55 (2013.01); C07K 2317/64 (2013.01); C07K 2317/94 (2013.01);
Abstract
The present invention relates to monomeric polypeptides comprising an engineered monomeric antibody fragment (e.g., monomeric Fc-containing polypeptides) wherein the monomeric Fc comprises one or more engineered N-linked glycosylation sites in the CH3-CH3 dimerization interface. Methods for producing such engineered monomeric antibody fragments and their use in diagnostics and therapeutics are also provided.