Location History:
- Palo Alto, CA (US) (1998 - 2005)
- Campbell, CA (US) (2002 - 2006)
Company Filing History:
Years Active: 1998-2006
Title: **Innovative Contributions of Robert M. Haefele in Polynucleotide Separation Technologies**
Introduction
Robert M. Haefele, a prolific inventor based in Campbell, California, holds a remarkable portfolio of 31 patents. His work has significantly advanced the fields of molecular biology and genetic analysis through innovative separation techniques for polynucleotides.
Latest Patents
Among his latest patents, Haefele has developed methods for the liquid chromatographic separation of polynucleotides. One notable invention involves a process for separating mixtures of DNA or RNA using a polymeric separation medium characterized by non-polar surfaces that are substantially free from multivalent cations, which can interfere with effective separation. This method also improves the separation of single-stranded polynucleotides at optimal temperatures.
Another significant contribution by Haefele is the modification of double-stranded DNA to enhance separations via Matched Ion Polynucleotide Chromatography (MIPC). By utilizing covalently bound non-polar tags to increase the retention times of double-stranded polynucleotides, his inventions improve the resolution of DNA mixture components. When these tags are integrally designed as fluorophores, they dramatically enhance detection sensitivity while allowing for precise mutation detection through the use of strategically tagged primers in conjunction with PCR techniques.
Career Highlights
Haefele's career at Transgenomic, Inc. has been marked by groundbreaking innovations that continue to reshape the methods used in genetic research and diagnostics. His extensive experience and unique approaches to polynucleotide separation have led to enhanced methodologies that are widely adopted in laboratories across the globe.
Collaborations
Throughout his career, Haefele has collaborated with esteemed colleagues such as Douglas T. Gjerde and Paul D. Taylor, further contributing to innovative projects and the sharing of knowledge in the field. These partnerships emphasize the importance of collaboration in scientific advancement, allowing for the cross-pollination of ideas leading to groundbreaking discoveries.
Conclusion
Robert M. Haefele’s contributions to the field of biotechnology, particularly in the area of polynucleotide separation, underscore the vital role of innovation in research and development. His inventions not only enhance the efficiency of genetic analysis but also set a precedent for future technologies that can further unravel the complexities of molecular biology.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.