Company Filing History:
Years Active: 2017-2023
Title: Innovations of Robert Layne Kruse
Introduction
Robert Layne Kruse is an accomplished inventor based in Houston, TX (US). He has made significant contributions to the field of medical therapies, particularly in the area of gene therapy and immunotherapy. With a total of 3 patents, his work focuses on innovative solutions for treating liver-related medical conditions.
Latest Patents
One of his latest patents is titled "Antibody based gene therapy with tissue-directed expression." This patent includes methods and compositions for treating medical conditions related to the liver, such as viral infections and liver cancer. The invention provides immunotherapies for delivering polynucleotides locally to the liver, which encode specific gene products, including bispecific antibodies targeting liver antigens.
Another notable patent is "Chimeric antigen receptor therapy with reduced cytotoxicity for viral disease." This patent encompasses immunotherapy for Hepatitis B viral (HBV) infection. It involves one or more chimeric antigen receptors (CAR) that target HBV antigens, utilizing specific scFv antibodies. The CARs are designed with mutations to reduce binding to Fc receptors, resulting in reduced cytotoxicity, which is particularly beneficial for immunocompromised individuals.
Career Highlights
Robert Layne Kruse has worked with prestigious institutions such as Baylor College of Medicine and Ribokine, LLC. His experience in these organizations has allowed him to develop and refine his innovative approaches to medical therapies.
Collaborations
Throughout his career, Kruse has collaborated with notable professionals, including Karl-Dimiter Bissig and Stephen M G Gottschalk. These collaborations have contributed to the advancement of his research and the successful development of his patents.
Conclusion
Robert Layne Kruse is a prominent inventor whose work in gene therapy and immunotherapy has the potential to significantly impact the treatment of liver diseases. His innovative patents reflect his dedication to advancing medical science and improving patient outcomes.