The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2017
Filed:
May. 13, 2014
Applicant:
Robert Kruse, Houston, TX (US);
Inventor:
Robert Kruse, Houston, TX (US);
Assignee:
Ribokine, LLC, Houston, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 15/115 (2010.01); C12Q 1/68 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); C12N 15/115 (2013.01); C12Q 1/6865 (2013.01); A61K 48/00 (2013.01); C12N 2310/16 (2013.01); C12N 2800/50 (2013.01); C12N 2830/42 (2013.01); C12N 2840/203 (2013.01); C12N 2840/44 (2013.01); C12N 2999/007 (2013.01);
Abstract
A circular mRNA molecule possessing features resembling native mammalian mRNA demonstrates improved translation, while retaining the properties of an extremely long half-life inside cells. This circular mRNA is functional inside mammalian cells, being able to compete against native cellular mRNAs for the eukaryotic translation initiation machinery. The invention possesses additional RNA elements compared to a previous invention containing only an IRES element for successful in vitro or in vivo translation.