Location History:
- Needham, MA (US) (1996 - 2023)
- Worcester, MA (US) (2019 - 2023)
Company Filing History:
14 out of 1,551 
8 out of 2,882 
1 out of 20 
Years Active: 1996-2025
Title: Robert H. Brown, Jr.: A Pioneer in Genetic Therapeutics
Introduction
Robert H. Brown, Jr. is a prominent inventor based in Needham, MA, renowned for his significant contributions to the field of genetic therapeutics. With a remarkable portfolio of 19 patents, Brown has focused his research on innovative approaches to genetic disorders, particularly those affecting the nervous system.
Latest Patents
Among his latest innovations, Brown has developed patents for SOD1 dual expression vectors which have promising implications for treating Amyotrophic Lateral Sclerosis (ALS). This invention includes compositions and methods aimed at inhibiting SOD1 expression in cells. The engineered nucleic acids he has created are designed to express an inhibitory nucleic acid targeting the endogenous SOD1 and also include an mRNA encoding a hardened SOD1 protein.
Another notable patent pertains to the use of antisense oligonucleotides for restoring dysferlin protein expression in patient cells suffering from dysferlinopathy. This invention focuses on modifying pre-mRNA splicing in the DYSF gene, aimed at addressing a novel mutation that results in a pseudoexon between exons 50 and 51.
Career Highlights
Robert H. Brown, Jr. has held significant positions at respected institutions such as the University of Massachusetts and The General Hospital Corporation, where he has had a lasting impact on genetic research and innovation. His work has opened up new pathways for understanding and treating complex genetic conditions.
Collaborations
Throughout his illustrious career, Brown has collaborated with notable researchers, including Christian Mueller and Janice A. Dominov. These collaborations have complemented his innovative spirit and advanced the research landscape in genetic therapies.
Conclusion
Robert H. Brown, Jr.'s contributions to science are underscored by his extensive patent portfolio and collaborative efforts. His innovative work continues to inspire advancements in the treatment of genetic disorders, particularly in the realm of neurodegenerative diseases.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.