The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2021
Filed:
Aug. 25, 2015
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Thomas J. Kwiatkowski, Jr., Cambridge, MA (US);
Robert H. Brown, Jr., Needham, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12P 19/34 (2006.01); C12Q 1/6883 (2018.01); G01N 33/68 (2006.01); C12N 15/113 (2010.01); C12Q 1/6837 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); C12N 15/1135 (2013.01); C12Q 1/6837 (2013.01); G01N 33/6896 (2013.01); C12N 2310/14 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/172 (2013.01); G01N 2800/28 (2013.01);
Abstract
The invention provides novel FUS/TLS nucleic acids and proteins that comprise one or more genetic markers (for example, single nucleotide polymorphisms) and methods of use thereof including methods relating to the diagnosis of ALS or other related motor neuron disease by virtue of the presence of the mutant FUS/TLS sequence(s).