Company Filing History:
Years Active: 2003-2018
Title: Richard Keith Bruick: Innovator in HIF-2α Inhibitors
Introduction
Richard Keith Bruick is a notable inventor based in Dallas, TX (US). He has made significant contributions to the field of medical research, particularly in the development of HIF-2α inhibitors for treating iron overload disorders. With a total of 3 patents, his work has the potential to impact therapeutic strategies for various health conditions.
Latest Patents
One of Bruick's latest patents focuses on HIF-2α inhibitors for treating iron overload disorders. This patent discusses methods of making and using these inhibitors, which have shown potency in various assays, including the HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay. The compounds developed under this patent have demonstrated the ability to reduce liver iron accumulation and serum iron parameters in both prophylactic and treatment mouse models.
Another significant patent involves the inhibition of HIF-2α heterodimerization with HIF1β (ARNT). This patent provides a method for inhibiting the heterodimerization of HIF-2α to HIF1β by binding specific small molecules to the HIF-2α PAS-B domain cavity. This innovative approach allows for the selective inhibition of HIF-2α heterodimerization without affecting HIF1α heterodimerization to HIF1β.
Career Highlights
Richard Keith Bruick is affiliated with the University of Texas System, where he continues to advance his research and innovation in the field of biochemistry and pharmacology. His work has garnered attention for its potential applications in treating iron overload disorders, showcasing his commitment to improving health outcomes through scientific discovery.
Collaborations
Throughout his career, Bruick has collaborated with esteemed colleagues, including Steven L McKnight and Yaomin Chen. These partnerships have contributed to the advancement of his research and the development of innovative solutions in the medical field.
Conclusion
Richard Keith Bruick is a prominent inventor whose work on HIF-2α inhibitors has the potential to revolutionize treatment options for iron overload disorders. His contributions to the field of medical research highlight the importance of innovation in addressing complex health challenges.