The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2017
Filed:
Nov. 14, 2013
The Board of Regents of the University of Texas System, Austin, TX (US);
Richard K. Bruick, Dallas, TX (US);
Charles G. Caldwell, Dallas, TX (US);
Doug E. Frantz, Boerne, TX (US);
Kevin H. Gardner, Carrollton, TX (US);
John B. MacMillan, Dallas, TX (US);
Thomas H. Scheuermann, Richardson, TX (US);
Uttam K. Tambar, Dallas, TX (US);
The Board of Regents of the University of Texas System, Austin, TX (US);
Abstract
Provided is a method of inhibiting heterodimerization of HIF-2α to HIF1β (ARNT) comprising binding certain small molecules to the HIF-2α PAS-B domain cavity but not to HIF1α and inhibiting HIF-2α heterodimerization to HIF1β (ARNT) but not inhibiting HIF1α heterodimerization to HIF1β (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2α heterodimerization inhibitors and also simply as certain small molecules.