The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Sep. 25, 2015
Applicant:
The Board of Regents of the University of Texas System, Austin, TX (US);
Inventors:
Richard Keith Bruick, Dallas, TX (US);
Yaomin Chen, Plano, TX (US);
Julio Cesar Francisco Ruiz, Garland, TX (US);
Assignee:
The Board of Regents of the University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/075 (2006.01); A61K 31/4965 (2006.01); A61K 31/085 (2006.01); A61K 31/10 (2006.01); A61K 31/145 (2006.01); A61K 31/277 (2006.01); A61K 31/415 (2006.01); A61K 31/416 (2006.01); A61K 31/4245 (2006.01); A61K 31/44 (2006.01); A61P 7/00 (2006.01); A61K 31/381 (2006.01); A61K 31/09 (2006.01); A61K 31/382 (2006.01); A61K 31/4436 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4965 (2013.01); A61K 31/09 (2013.01); A61K 31/10 (2013.01); A61K 31/145 (2013.01); A61K 31/277 (2013.01); A61K 31/381 (2013.01); A61K 31/382 (2013.01); A61K 31/415 (2013.01); A61K 31/416 (2013.01); A61K 31/4245 (2013.01); A61K 31/44 (2013.01); A61K 31/4436 (2013.01);
Abstract
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating iron overload disorders. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and reduced liver iron accumulation and serum iron parameters in both prophylactic and treatment mouse models.