This inventor holds 11 USPTO granted patents. Top assignees: Dana-Farber-Cancer Institute Inc., Oregon Health & Science University, University of Vermont. Active years: 1998-2008.
Location History:
- Jamaica Plain, MA (US) (1998 - 2008)
- San Diego, CA (US) (2002 - 2008)
Company Filing History:
8 out of 1,265 
2 out of 524 
2 out of 248 
Years Active: 1998-2008
Title: Richard D. Kolodner: Innovator in DNA Mismatch Repair Pathways
Introduction
Richard D. Kolodner is a prominent inventor known for his significant contributions to the field of genetics and cancer research. He is based in Jamaica Plain, MA (US) and holds a total of 11 patents. His work primarily focuses on the DNA mismatch repair pathway, which has critical implications for understanding and diagnosing various cancers.
Latest Patents
Kolodner's latest patents include groundbreaking methods for detecting alterations in the DNA mismatch repair pathway. He discovered that eukaryotes, including mammals, possess a DNA mismatch repair pathway similar to that found in bacteria. Defects in this pathway can lead to the accumulation of unstable repeated DNA sequences, which are highly correlated with several cancer states, particularly hereditary colon cancers. His findings suggest that identifying defects in this pathway can serve as a diagnostic tool for cancer predisposition and prognosis. Additionally, he has sequenced a gene in this pathway, known as MSH2, which has numerous applications in assays, gene expression, drug screening, and therapeutic interventions. Another significant patent involves the detection of alterations in the MSH5 gene, which also plays a role in cancer diagnostics and therapeutics.
Career Highlights
Throughout his career, Kolodner has made substantial contributions to cancer research and genetics. His innovative methods and discoveries have advanced the understanding of DNA repair mechanisms and their implications for cancer. He has worked with esteemed institutions, including the Dana-Farber Cancer Institute, where he has furthered his research and collaborations.
Collaborations
Kolodner has collaborated with notable colleagues such as Roni J. Bollag and C. Eric Bronner, contributing to a rich environment of research and innovation in the field of genetics.
Conclusion
Richard D. Kolodner's work in the area of DNA mismatch repair pathways has paved the way for significant advancements in cancer diagnostics and therapeutics. His innovative patents and collaborations continue to influence the field and enhance our understanding of genetic disorders.