Company Filing History:
Years Active: 2022-2025
Title: Innovations of Rachel Cathleen Botham
Introduction
Rachel Cathleen Botham is a prominent inventor based in Burlingame, CA. She has made significant contributions to the field of biotechnology, particularly in the development of engineered polypeptides for therapeutic applications. With a total of three patents to her name, her work has the potential to impact various medical treatments.
Latest Patents
One of her latest patents focuses on human alpha-galactosidase variants. This invention provides engineered human alpha-galactosidase polypeptides and compositions that have been optimized for improved thermostability, serum stability, and cellular uptake. The polypeptides are designed to function effectively under both acidic and basic conditions, while also reducing immunogenicity and enhancing the removal of globotriaosylceramide from cells. Another significant patent involves engineered acid alpha-glucosidase variants. This invention offers engineered acid alpha-glucosidase polypeptides that have been optimized for increased expression, stability at neutral pH, and activity in cell lysates. The methods for utilizing these compositions for therapeutic purposes are also outlined in the patent.
Career Highlights
Rachel has worked with notable companies in the biotechnology sector, including Codexis, Inc. and Crosswalk Therapeutics, Inc. Her experience in these organizations has contributed to her expertise in the development of innovative therapeutic solutions.
Collaborations
Throughout her career, Rachel has collaborated with esteemed colleagues such as William Casey Hallows and Yu Zhu. These partnerships have further enriched her research and development efforts.
Conclusion
Rachel Cathleen Botham is a trailblazer in the field of biotechnology, with her innovative patents paving the way for advancements in therapeutic treatments. Her contributions are poised to make a lasting impact on the medical community.