The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2025
Filed:
Mar. 20, 2024
Crosswalk Therapeutics, Inc., Cambridge, MA (US);
William Casey Hallows, San Francisco, CA (US);
Rachel Cathleen Botham, Burlingame, CA (US);
Yu Zhu, Newark, CA (US);
Chinping Chng, Menlo Park, CA (US);
Nikki Dellas, San Carlos, CA (US);
Gjalt W. Huisman, Redwood City, CA (US);
Moulay Hicham Alaoui Ismaili, San Mateo, CA (US);
David William Homan, San Ramon, CA (US);
Adam P. Silverman, San Carlos, CA (US);
Jonathan Vroom, South San Francisco, CA (US);
Jessica P. Lao, San Carlos, CA (US);
Crosswalk Therapeutics, Inc., Cambridge, MA (US);
Abstract
The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.