The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2022
Filed:
Dec. 19, 2019
Codexis, Inc., Redwood City, CA (US);
William Casey Hallows, San Francisco, CA (US);
Kristen Jean Vallieu, Union City, CA (US);
Nikki Dellas, Mountain View, CA (US);
Yu Zhu, Newark, CA (US);
Judy Victoria Antonio Viduya, South San Francisco, CA (US);
Chinping Chng, Menlo Park, CA (US);
Antoinette Sero, Foster City, CA (US);
Gjalt W. Huisman, Redwood City, CA (US);
Rachel Cathleen Botham, Burlingame, CA (US);
Moulay Hicham Alaoui Ismaili, San Mateo, CA (US);
Codexis, Inc., Redwood City, CA (US);
Abstract
The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH<4) and basic (pH>7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.