Company Filing History:
Years Active: 2021-2025
Title: Antoinette Sero: Innovator in Enzyme Engineering
Introduction
Antoinette Sero is a prominent inventor based in Foster City, CA, known for her significant contributions to the field of enzyme engineering. With a total of four patents to her name, she has made remarkable advancements in the development of engineered enzymes that have various applications in therapeutic and industrial processes.
Latest Patents
Among her latest patents is the invention of carboxyesterase polypeptides for amide coupling. This invention provides engineered carboxyesterase enzymes that exhibit improved properties compared to naturally occurring wild-type enzymes. The patent also includes polynucleotides encoding these engineered enzymes, host cells capable of expressing them, and methods for utilizing these enzymes in amidation reactions. Another notable patent is for human alpha-galactosidase variants. This invention presents engineered human alpha-galactosidase polypeptides that have been optimized for enhanced thermostability, serum stability, and improved cellular uptake. These polypeptides are designed to function effectively under both acidic and basic conditions, while also reducing immunogenicity and improving the removal of globotriaosylceramide from cells for therapeutic purposes.
Career Highlights
Antoinette has worked with notable companies such as Codexis, Inc. and Crosswalk Therapeutics, Inc. Her work in these organizations has allowed her to apply her innovative ideas and contribute to the advancement of enzyme technology.
Collaborations
Throughout her career, Antoinette has collaborated with talented individuals, including Nikki Dellas and William Casey Hallows. These collaborations have further enriched her work and expanded the impact of her inventions.
Conclusion
Antoinette Sero's contributions to enzyme engineering through her patents and collaborations highlight her role as a leading innovator in the field. Her work continues to influence advancements in therapeutic applications and enzyme technology.