Location History:
- Gaitherburg, MD (US) (2012)
- Berwyn, PA (US) (2000 - 2015)
Company Filing History:
7 out of 2,198 
1 out of 144 
1 out of 410 
Years Active: 2000-2015
Title: The Innovative Contributions of Ping Tsui
Introduction
Ping Tsui is a notable inventor based in Berwyn, PA (US), recognized for his significant contributions to the field of antibody discovery. With a total of 11 patents to his name, Tsui has made remarkable advancements in the development of synthetic Fab libraries and therapeutic antibodies.
Latest Patents
Among his latest patents, Tsui has developed combinatorial synthetic Fab libraries displayed on a phage pIX protein. These libraries were constructed using scaffolds that represent the most frequently utilized genes in human antibodies, diversified to reflect the variability of natural antibodies. Through a selection process involving a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. Notably, the affinity of some antibodies was enhanced by up to one hundred-fold through a process called in-line maturation, resulting in low pM binders suitable for in vivo applications. This work demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and establishes a foundation for further studies on the structure-function relationship of antibodies. Additionally, he has patented novel anti-MCP-1 antibodies, including isolated nucleic acids that encode these antibodies, along with methods for their therapeutic use.
Career Highlights
Throughout his career, Ping Tsui has worked with prominent organizations, including SmithKline Beecham Corporation. His work has significantly impacted the field of biotechnology and therapeutic development.
Collaborations
Tsui has collaborated with esteemed colleagues such as Nabil A Elshourbagy and Pamela A Lane, contributing to various innovative projects and research initiatives.
Conclusion
Ping Tsui's innovative work in the field of antibody discovery and development has led to significant advancements, as evidenced by his numerous patents and collaborations. His contributions continue to influence the biotechnology landscape and pave the way for future research.