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Years Active: 2018-2019
Title: The Innovative Contributions of Philip W. Noble
Introduction
Philip W. Noble is a distinguished inventor based in New Haven, CT, known for his significant contributions to cancer therapy through innovative antibody-based treatments. With a total of two patents to his name, Noble has focused on addressing the challenges of delivering therapeutic agents into cancer cells, particularly those with specific genetic mutations.
Latest Patents
Noble's latest patents include groundbreaking work in cancer therapy. The first patent, titled "Cell penetrating nucleolytic antibody based cancer therapy," addresses the susceptibility of cancer cells with defects in DNA repair to DNA-damaging agents. This invention utilizes a subset of autoantibodies with nucleolytic activity that can penetrate cell nuclei, making them effective therapeutic agents for DNA repair-deficient malignancies. The second patent, "Cell penetrating anti-guanosine antibody based therapy for cancers with Ras mutations," focuses on the delivery of antibodies that bind intracellular guanosine. This therapy targets cancer cells with oncogenic mutants in the small GTPase K-Ras, utilizing lupus autoantibodies capable of cellular penetration.
Career Highlights
Throughout his career, Philip W. Noble has worked with prestigious institutions, including Yale University and the United States Government as represented by the Department of Veterans Affairs. His work has significantly advanced the field of cancer therapy, particularly in developing innovative methods to deliver therapeutic agents effectively.
Collaborations
Noble has collaborated with notable colleagues, including James E. Hansen and Richard H. Weisbart, contributing to the advancement of research in cancer therapies.
Conclusion
Philip W. Noble's innovative work in antibody-based cancer therapies showcases his commitment to improving treatment options for patients with specific genetic mutations. His patents reflect a deep understanding of the challenges in cancer treatment and a dedication to finding effective solutions.