The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2019
Filed:
Jun. 25, 2015
Yale University, New Haven, CT (US);
The United States of America As Represented BY the Department of Veteran Affairs, Washington, DC (US);
James E. Hansen, Guilford, CT (US);
Richard H. Weisbart, Los Angeles, CA (US);
Philip W. Noble, New Haven, CT (US);
Yale University, New Haven, CT (US);
The United States of America as Represented by the Department of Veterans Affairs, Washington, DC (US);
Abstract
Cancer cells with defects in DNA repair are highly susceptible to DNA-damaging agents, but delivery of therapeutic agents into cell nuclei can be challenging. A sub-set of autoantibodies having nucleolytic activity are capable of nuclear penetration. These antibodies can be used as therapeutic agents targeted towards DNA repair-deficient malignancies.