The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2018
Filed:
Mar. 04, 2015
Yale University, New Haven, CT (US);
The United States of America As Represented BY the Department of Veterans Affairs, Washington, DC (US);
James E. Hansen, Guilford, CT (US);
Richard H. Weisbart, Los Angeles, CA (US);
Melissa Young, New Haven, CT (US);
Philip W. Noble, New Haven, CT (US);
Yale University, New Haven, CT (US);
The United States of America, as Represented by The Department of Veterans Affairs, Washington, DC (US);
Abstract
It has been established that cancer cells with oncogenic mutants in the small GTPase K-Ras are susceptible to antibodies that bind intracellular guanosine, but delivery of antibodies into cells can be challenging. A subset of lupus autoantibodies is associated with anti-guanosine activity, and is capable of cellular penetration. These antibodies have potential as therapeutic agents targeted towards K-Ras associated malignancies.